Re: mirapex

Posted by linkadge on July 4, 2010, at 12:18:03

In reply to Re: mirapex » inanimate peanut, posted by Conundrum on July 4, 2010, at 0:52:36

For me, using an SSRI seems to prevent tollerance (to some extent) to the ritalin. Actually, I have been using chlorpheniramine which is an antihistamine with affinity for the serotonin transporter.
The problem is when I use the long acting SSRI's I get dysphoria. Chlorpheniramine is relatively short acting, and has effects on depression itself in animal models.
I take 1-2mg in the evenining which helps sleep, with little/no hangover. It also seems to help keep the ritalin working the next day.
Chlorpheniramine has some muscarinic antagonism which could (theoretically) augment the dopaminergic effect of the ritalin.

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