Posted by ed_uk2010 on July 5, 2010, at 14:47:57
In reply to Re: what is 50mg anafranil = to as SSRI ?, posted by Brainbeard on July 5, 2010, at 13:04:34
> I once switched from 150mg fluvoxamine (Luvox) to 10mg clomipramine. Based on the study quoted, >I thought 10mg clomipramine should be enough to compensate for the loss of SRI by quitting fluvoxamine. It wasn't by far enough to counter fluvoxamine's withdrawal syndrome, though. Subjectively, 10mg of clomipramine was more in the neighbourhood of placebo..........I think that about 40, 50mg of clomipramine could be enough to provide robust SRI
According to one of the graphs in the article that you posted a link to, 10mg clomipramine appears to give less than 80% occupancy. 20mg gave more than 80%, both after a single dose and on repeated dosing. I expect you are correct that 40-50mg would provide robust serotonin reuptake inhibition. I've seen a clinical study which used 30mg per day for depression.
poster:ed_uk2010
thread:952518
URL: http://www.dr-bob.org/babble/20100628/msgs/953388.html