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Nortriptyline and weight gain

Posted by ed_uk2010 on August 8, 2010, at 12:02:04

In reply to Re: Nortryptaline and weight gain » ed_uk2010, posted by Maxime on August 8, 2010, at 9:09:37

> Thanks Ed. Do you know HOW it makes you gain weight? Does it make you eat more? Or does it slow down the metabolism?

It does sometimes increase appetite; this may occur due to histamine and serotonin receptor blockade. The exact mechanism by which TCAs cause weight gain is not known. It has been suggested that it may involve tumour necrosis factor.

http://www.ncbi.nlm.nih.gov/pubmed/10869882

 

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