Posted by Conundrum on August 27, 2010, at 7:37:43
In reply to Re: Abilify for anhedonia » Conundrum, posted by SLS on August 27, 2010, at 7:00:17
It does increase dopamine in the PFC but not norepinephrine, unlike some other antipsychotics like olanzapine. I think both NE and DA are necessary to combat anhedonia. Just my opinion. Seroquel might be better, since its metabolite, nor-quetiapine, is a norepinephrine is a reuptake inhibitor.
Here is more info on abilify's PFC effects.
http://www.ncbi.nlm.nih.gov/pubmed/16023290
Aripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex.Zocchi A, Fabbri D, Heidbreder CA.
Centre of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, Neuropsychopharmacology, Via A. Fleming 4, 37135 Verona, Italy. alessandro.a.zocchi@gsk.com
AbstractAripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the prefrontal cortex of freely moving C57BL/6J mice. Concurrent horizontal locomotor activity was also assessed. Aripiprazole produced a significant increase in dialysate DA levels after the administration of a low dose of 0.3mg/kg. Lower (0.1 mg/kg) or higher (3 and 30 mg/kg) doses failed to affect extracellular levels of DA. In addition, none of the doses tested in the present study produced significant changes in extracellular levels of noradrenaline (NA) and serotonin (5-HT). For the sake of comparison, clozapine (0, 3 and 10 mg/kg, s.c.) was also tested under similar conditions. Clozapine produced a dose-dependent increase in both dialysate DA and NA levels without affecting extracellular 5-HT. Locomotor activity was significantly decreased by both clozapine and aripiprazole. These data further support the hypothesis that selective activation of dopaminergic neurotransmission in the prefrontal cortex may contribute to the therapeutic efficacy of aripiprazole.
PMID: 16023290 [PubMed - indexed for MEDLINE]
Iatrogenic post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. (not a formal DX)
Country:USA
Currently taking Lamictal, mirtazapine, and abilify.
poster:Conundrum
thread:926202
URL: http://www.dr-bob.org/babble/20100821/msgs/960128.html