Posted by proudfoot on September 8, 2010, at 21:52:47
In reply to Re: Whats good to augment with Nardil? » angels78, posted by Tomatheus on September 8, 2010, at 18:28:01
Or, from a counter-intuitive perspective, is the dose actually too high? The drug manufacturer recommends 60-90 mg for a sustained period of at least four weeks to attain full MAO inhibition and then a gradual reduction in dosage for maintenance therapy:
"The usual starting dose of Nardil is one tablet (15 mg) three times a day.
*Early phase treatment: Dosage should be increased to at least 60 mg per day at a fairly rapid pace consistent with patient tolerance. It may be necessary to increase dosage up to 90 mg per day to obtain sufficient MAO inhibition. Many patients do not show a clinical response until treatment at 60 mg has been continued for at least 4 weeks.
*Maintenance dose: After maximum benefit from Nardil is achieved; dosage should be reduced slowly over several weeks. Maintenance dose may be as low as one tablet, 15 mg, a day or every other day, and should be continued for as long as is required."Anyone out there an expert in MAO physiology want to comment on this? I'm curious about this myself as I approach the end of my third week of Nardil 60 mg daily. My take on the above is to hit it hard early on and then back off to the lowest effective dose to minimize side effects.
Doug
> > Do you think the reason that 60 mg isn't working is because of my weight? I weigh 200 lbs. I once read that nardil dosage should be around 1MG per 2.2 lbs.
>
> angels78,
>
> I certainly think it's possible that the reason you're not responding to 60 mg of Nardil could be because you're not taking enough for your weight. I too have read about the 1 mg/kg (1 mg/2.2 lbs) rule, so it makes sense that you might not be taking enough. I would still personally give it some more time at 60 mg, though, since 60 mg is considered to be at the bottom of the therapeutic dose range for Nardil.
>
> Good luck getting a good response out of Nardil.
>
> Tomatheus
poster:proudfoot
thread:961534
URL: http://www.dr-bob.org/babble/20100908/msgs/961744.html