Posted by linkadge on September 10, 2010, at 7:52:20
In reply to Re: Another semi failed trial » linkadge, posted by SLS on September 10, 2010, at 5:15:35
>What would be the effect of the partial 5-HT1a >autoreceptor (somatodendritic?) agonism Abilify >exhibits?
I'm not sure. Does it have any post synaptic efficacy at 5-ht1a?
The acute effects of agonizing 5-ht1a autoreceptors would be to decrease overall serotoninergic firing. This might be expected to increase dopamine release in certain brain regions which are under inhibitory control by serotonin.
OHOT, chronic administration might desensitize the autoreceptors, thus increasing serotonergic functioning and producing the reverse action.
It really depends on the brain region and the serotonin receptor involved. For instance, in the frontal cortex, post synaptic 5-ht1a agonism increases dopamine release, wheras 5-ht2c agonism decreases it.
Linkadge
poster:linkadge
thread:961768
URL: http://www.dr-bob.org/babble/20100908/msgs/961903.html