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Re: dumb drug » Brainbeard

Posted by SLS on October 11, 2010, at 7:00:27

In reply to Re: dumb drug, posted by Brainbeard on October 11, 2010, at 5:55:16

> > Is it just me or does clomipramine possibly have the worst cognitive side-effects of any legitimate AD? It feels like the drug is punching holes in my brain, which is quite a feat, given that I was severely depressed before trialling it. 90% of my vocabulary is missing; when I try and think simple, everyday thoughts, it's like my brain lacks the language to fill in what I'm thinking.

> Well, the TCA's do tend to cause much more cognitive dumbing than the newer antidepressants. Your ability to think and speak may (partially) recover in the course of treatment; when I was on 75mg of clomipramine two years ago, I suffered from much worse cognitive dumbing than I do now on 225mg!

Yes. I was going to suggest giving clomipramine a bit more time and focus less on the cognitive side effects that are more robust at the beginning of treatment. Cognitive impairment might be the consequence on the anticholinergic effects of clomipramine. However, things like having trouble with word finding and brain fog can just as easily be attributed to its pro-serotonergic actions.

I may be a bit premature in my suggestion.

What are you being treated for and why was clomipramine started? How long are you on it and what dosage are you at. Sorry if these are redundant questions.


- Scott



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The measure of success lies only in how high one feels he must
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