Posted by ed_uk2010 on November 8, 2010, at 13:36:48
In reply to Metoclopramide + Promethazine - antipsychotics?, posted by jerryTRD on November 7, 2010, at 20:43:11
>For you self-taught pharmacologists out there - are these two meds old cousins of antipsychotics?
Promethazine is a phenothiazine. It is related to chlorpromazine. Its dopamine blocking action is considerably weaker than chlorpromazine and its antipsychotic activity is minimal. There are very few reports of TD with promethazine.
Metoclopramide is a benzamide. It is structurally very different to the phenothiazines, and is more similar to sulpiride and amisulpride. Although metoclopramide can cause EPS, it is not believed to be an effective antipsychotic.
poster:ed_uk2010
thread:969050
URL: http://www.dr-bob.org/babble/20101107/msgs/969224.html