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Tricyclics increase CVD risk

Posted by Tomatheus on November 30, 2010, at 22:42:29

From MedPage Today:

Tricyclics Increase CVD Risk

By Nancy Walsh, Staff Writer, MedPage Today
Published: November 30, 2010
Reviewed by Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine.

Growing concern that patients taking tricyclic antidepressants are at increased risk for cardiovascular disease has been proven out in a large European study.

In a prospective cohort study that included 14,784 adults, those using tricyclics had a 35% increased cardiovascular risk after adjustment for potential confounders including symptoms of depression and anxiety, which are known risk factors for cardiovascular disease (HR 1.35, 95% CI 1.03 to 1.77).

In contrast, the use of selective serotonin reuptake inhibitors (SSRIs) was not associated with an elevated risk (HR 1.11, 95% CI 0.77 to 1.60), Mark Hamer, PhD, of University College London, and colleagues reported online in the European Heart Journal.

Read full article:
http://www.medpagetoday.com/Geriatrics/Depression/23662


Diagnosed with schizoaffective disorder. Currently taking 5 mg Abilify, 12.5 mg Lamictal, 2.25 mg Hydergine, and four supplements.


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