Posted by vasco378 on December 20, 2010, at 10:02:10
Hi all, I am a newbie to this forum and have a burning question.
I take tranylcypromine (20mg/day), and am considering adding reboxetine or atomoxetine. This is because these two drugs are potent noradrenaline reuptake inhibitors which may provide a strong protective effect against tyramine induced hypertensive crsis. Well at least this research found this to be the case:
http://www.ncbi.nlm.nih.gov/pubmed/7931221
In fact the "tyramine pressor response test" is a test often used to test the ability of a drug to block noradrenaline re-uptake. The more able a drug is in preventing tyramine induced blood pressure increases the stronger the noradrenaline re-uptake it has.
Does anyone have experience of combining tranylcypromine with reboxetine, atomoxetine or other noradraneline re-uptake inhibitirs? Did it seem to help prevent hypertensive crisis or blood pressure rises? Did it affect the efficacy of the tranylcypromine?
Any insights would be awesome...
poster:vasco378
thread:974105
URL: http://www.dr-bob.org/babble/20101218/msgs/974105.html