Posted by pedr on February 3, 2011, at 14:45:27
In reply to Re: Questions On Depression and Nardil » pedr, posted by Chairman_MAO on February 3, 2011, at 14:31:15
> >For instance, there is no research whatsoever on the body weight 1kg / 1mg ratio. It's a rule-of-thumb that some psychs employ but certainly not all. My (competent) psych had never heard of it.
>
> You are wrong, and so is your doctor--unless you misrepresented what he said, which is possible.
>
> "Clinical response to phenelzine is related to platelet MAO inhibition and dosage per unit body weight."
>
> http://www.ncbi.nlm.nih.gov/pubmed/365127
>
> And that's from 1978! Nothing earth-shattering here.
>
> Yes, it is a heuristic, and clinical response matters most. However, it is based on research: unless you get blood work done and follow platelet MAO, one should titrate to desired effect, which seems to happen around 1mg/kg/day. People with abnormal liver function, etc., need not apply.
>
> I have no medical degree, but I can read and understand concepts.
>
> "No research whatsoever" is a strong statement!
>Hah! and it's the top hit if you google "phenelzine body weight" too. I stand very much corrected - apologies for the incorrect information. I've participated in several threads where the 1mg / 1kg rule has been generally acknowledged as an unproven/unfounded rule-of-thumb. I guess I just incorrectly concluded that as a fact.
In that case, thanks to my "Nardil belly" I should be on 105mg <gulp>
Pete
Treatment Resistant depression, anxiety, OCD: 13 years
IBS-C & GERD: 8 years
Current meds: 90mg Nardil, 300mg Zantac, 20mg Prilosec
poster:pedr
thread:976577
URL: http://www.dr-bob.org/babble/20110130/msgs/978613.html