Posted by bodhisattva_guy on February 10, 2011, at 0:04:12
In reply to Re: Latuda - Opinions, posted by Phillipa on February 9, 2011, at 13:39:47
Oh you two! Respecfully, without confrontation, I'll just add the info which might be relevant to some:
"Lurasidone has a unique receptor-binding capability with high affinity for dopamine-2, serotonin-2A, serotonin-7, serotonin-1A and noradrenaline-2c receptors. These receptors are known to improve cognitive capabilities upon effective regulation. The drug has limited affinity for histamine-1 and acetylcholine-M1 receptors. Lurasidone is also a partial agonist for the serotonin 5HT1A receptor. It enhances the functions of muscarinic acetylcholine receptors, which are known to aid in memory and learning functions.
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In clinical trials, Lurasidone has shown its efficacy in treating both positive and negative symptoms of schizophrenia. Significant improvements in the cognitive symptoms have also been noticed with the use of the drug. The safety profile of the drug is also good with minimal weight gain and metabolic effects. As a result, use of Lurasidone may not necessitate co-administration of anti-cholinergics, which are known to impair cognition.Lurasidone clinical trials
The development of Lurasidone involved more than 40 clinical trials. Phase II trials included two six-week randomised double-blind placebo-controlled studies carried out across the US. The studies indicated that Lurasidone was well tolerated in patients and showed greater efficacy compared to the placebo group.
Phase III studies of Lurasidone included two Program to Evaluate the Antipsychotic Response to Lurasidone (PEARL) trials conducted across the world. PEARL 1 was a six-week placebo-controlled double-blind, trial which started in October 2007. The study recruited 500 patients in 51 centres across the US, Europe and Asia. The majority of the patients recruited were male with an average age of 39 years.
In May 2009, DSP announced positive results from PEARL 1 study. The results indicated that Lurasidone was more effective in treating acute schizophrenia compared with the placebo."
- http://www.drugdevelopment-technology.com/projects/lurasidone/I wonder why will we see trials of efficacy of this new drug versus older atypicals?
Perhaps there is one, I have browsed pubmed yet
poster:bodhisattva_guy
thread:978987
URL: http://www.dr-bob.org/babble/20110130/msgs/979031.html