Posted by ed_uk2010 on March 29, 2011, at 13:38:28
In reply to Nortriptyline vs reboxetine, posted by jono_in_adelaide on March 28, 2011, at 19:57:42
> Hi, I am a sufferer of the holy trinity of depression, GAD and panic disorder.
>
> Current meds are Sertraline (Zoloft) 100mg daily, reboxetine (Edronax) 4mg twice daily, and Xanax 1mg as needed, usualy twice daily.
>
> I recently read that the BMJ had reviewed reboxetine and found it an "ineffective and thus dangerous antidepressant" (though it worked well for me, Zolfot alone did SFA for my depression, where as adding edronax had me feeling better within a fortnight) Given this poor rating, should I look at changing my NARI from reboxetine to nortriptyline (the only other reasonably clean NARI on the market in Australia, desipramine being discontinued some years ago)
>
> What I am taking now works reasonably well, but wondering if Zoloft + Nortriptyline might work even better?I don't believe that Edronax is ineffective. I think it's effective for a subset of patients... just a smaller proportion than SSRIs and TCAs.
Nortriptyline is quite different to Edronax. It's much more likely to cause drowsiness and weight gain. Some other side effects may be less common, however.
I certainly don't think you should change meds because of what the BMJ said - it's your own personal response that counts, not how other patients respond.
poster:ed_uk2010
thread:981366
URL: http://www.dr-bob.org/babble/20110321/msgs/981402.html