Posted by desolationrower on April 3, 2011, at 0:38:32
In reply to Re: Drugs that increase REM sleep?, posted by psychobot5000 on April 2, 2011, at 15:22:09
>
> In any case, I'm trying to improve sleep without disrupting structure. So let's try another tack: what pharmaceutical sleep aids DO NOT suppress REM? Any ideas? Do benzodiazepines suppress it? I know Halcion is supposed to, but what about the rest?
>yeah, benzos don't. but the thing is, the general model is: sleep starts out normal/structured. Then you get depressed, and REM increases, REM and light sleep and wakingi interfere with deep sleep and the order gets more random. But, if you take an antidepressant, your sleep structure improves: REM supression, and thus more deep sleep.
So unless you have a sleep study showing that you are sleeping with LOOOTTTS of deep sleep and no REM, i'm kind of skeptical that you would like the results of more REM.
> Also: does anyone know why opiates seem to affect REM? In my experience, buprenorphine/suboxone seems to actually increase dreaming (which I assume translates to increased REM), and I'm wondering why that would be. (I suppose it could have something to do with its partial agonism, rather than full agonism, of mu opiate receptors, or the fact that it's apparently a powerful antagonist of kappa opiate receptors, in contrast to other meds...but I'm really just guessing).erm, i would guess some sort of structural reason periaductual grey or something is relevant, but i don't actually remember anything about it. I skip most htings on opiods, since they are mostly unavailble tools. sorry.
oh and "subjective dreaming" = woke up during REM, for the most part.
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:980994
URL: http://www.dr-bob.org/babble/20110321/msgs/981804.html