Posted by linkadge on April 5, 2011, at 14:24:34
In reply to Re: Continuing Acytel-Choline discusion, posted by mtdewcmu on April 5, 2011, at 12:02:43
>Having said that, there is a great deal of >Evidence that Excess Acetyl-choline is >implicated in mood & neurological disorders.
>For example Parkinson's patients have increased >Acetyl-choline levelsI didn't know about that. Its true that parkinsons patients sometimes use anticholinergics to improve certain symptoms
but this is because anticholinergics indirectly promote dopamine release (in certain brain regions).However, its much more complex than that. Consider nicotine. Nicotine is a acetycholine agonist, yet it increases dopamine release and has theraputic effect in certain parkinsons cases.
There are many acetycholine recpetors with opposing actions. I believe the muscarinic M1 receptors have been the most studied in terms of depression.
The flinders senstive mouse line (a rat model of depression) has higher levels / affinity for the m1 receptor. It does not have elevated levels of acetycholine per se however.
Stress can increase the sentivity of the m1 receptor towards acetycholine.
Linkadge
poster:linkadge
thread:982007
URL: http://www.dr-bob.org/babble/20110321/msgs/982019.html