Posted by SLS on April 28, 2011, at 5:35:47
In reply to nardil dose v MAO inhibition, posted by viper1431 on April 28, 2011, at 1:38:43
> Hi, just wondering in the case of moclobemide the wiki article states "A single 300 mg dose of moclobemide inhibits 80% of monoamine oxidase A (MAO-A) and 30% of monoamine oxidase B (MAO-B),"
Moclobemide actually binds quite loosely at first and then more tightly later on. It is suggested that there is a metabolite of moclobemide that is responsible for the relatively higher affinity for the MAO-A enzyme.
> I was wondering if anyone knows what this would be in the case of nardil, ie X dosage of nardil inhibits xx % of MAO ..
> cheers/I can't comment on Nardil, but Parnate 60 mg yielded almost total MAO blockade for me. Maybe Nardil would be closer to 75 mg. Some people swear by calculating the effective dosage of Nardil by using 1 mg/kg body weight. I am a good example of this. I weigh (a disgusting) 200 lbs (90 kg), which equates 90 mg of Nardil.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:983922
URL: http://www.dr-bob.org/babble/20110418/msgs/983942.html