Posted by SLS on April 30, 2011, at 6:36:57
In reply to High Neurontin (Gabapentin) dose, posted by tepi on April 28, 2011, at 23:25:16
>
> I keep going up on this med because I developed tolerance to it... I started with only 300mg /day
> I am taking now 2000mg in the morning and 1200mg in the afternoon.
> It seems this is not goona work
>
> what should I do ????
>
> Social phobia I want to cure !Gabapentin has been thought to treat social phobia for quite awhile. More recently, it has been studied systematically using double-blind investigations.
http://www.ncbi.nlm.nih.gov/pubmed/10440462
I would look towards an SRI like paroxetine or venlafaxine, or a MAOI - Nardil specifically. You can then add gabapentin as an augmenter if these drugs fail to produce a robust therapeutic effect.
I may be wrong, but I have been under the impression that paroxetine is more effective than the other SSRIs. If side effects are deemed unacceptable, my guess is that any other SSRI would substitute for paroxetine, with the possible exception of fluoxetine (it can be anxiogenic). Paroxetine might be the most offensive regarding weight gain and sexual dysfunction. However, I did not experience these things when I tried it. Escitalopram might make a good substitute.
I believe 3600 mg of gabapentin is the upper bound above which no added benefit can be gained. Gabapentin is saturable with logorithmic dose curve. It is all excreted in the urine without being metabolized. Pregabalin is much more bioavailable as the dosage increases.
http://www.ncbi.nlm.nih.gov/pubmed/20818832
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:984035
URL: http://www.dr-bob.org/babble/20110418/msgs/984147.html