Posted by desolationrower on June 11, 2011, at 12:59:29
In reply to Re: has anyone done ketogenic diet + antidepressants » morgan miller, posted by 49er on April 20, 2011, at 1:41:16
Norepinephrine is required for the anticonvulsant effect of the ketogenic diet.
Szot P, Weinshenker D, Rho JM, Storey TW, Schwartzkroin PA.
SourceGeriatric Research, Education and Clinical Center (GRECC) (182B), VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA. szot@u.washington.edu
AbstractKetogenic diet (KD) is a high fat, low carbohydrate diet used to treat children with epilepsy that are refractory to conventional antiepileptic drugs (AEDs). The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine beta-hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD. When exposed to the convulsant flurothyl, Dbh +/- mice fed the KD had significantly longer latencies to myoclonic jerk (MJ) and generalized clonic-tonic (CT) seizures than Dbh +/- mice fed normal chow. In contrast, Dbh -/- mice fed the KD had seizure latencies to both MJ and CT comparable to Dbh -/- mice fed normal chow. These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect.
PMID:
11506865
[PubMed - indexed for MEDLINE]
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:981091
URL: http://www.dr-bob.org/babble/20110610/msgs/987735.html