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Re: antipsychotic update!!! » sigismund

Posted by SLS on June 18, 2011, at 4:47:08

In reply to Re: antipsychotic update!!! » SLS, posted by sigismund on June 17, 2011, at 20:58:54

> >What about taking into consideration 5-HT2a antagonism?
>
> Hi Scott, why would you do that?
>
> Is that low dose Prozac?

When the population of 5-HT2a receptors in the prefrontal cortex (PFC) is inhibited from firing, it effectively releases the brakes on dopamine (DA) and norepinephrine (NE) activity there. The atypical antipsychotics are potent 5-HT2a antagonists and are generally capable of treating the negative symptoms (deficit syndrome) of schizophrenia. Several antidepressants also antagonize the 5-HT2a receptor. Nortriptyline is one that comes to mind.

Prozac antagonizes 5-HT2c receptors. Interestingly, Prozac is the only AD that I am aware of that increases the release of DA and NE acutely in the PFC.


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

 

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