Posted by Conundrum on August 24, 2011, at 23:56:08
In reply to Re: Is Pristiq really much different then Effexor ?, posted by jono_in_adelaide on August 24, 2011, at 22:19:16
> Scott, I'm not quite sure what you mean, I have no hypothesis, I was just making a statement thatt he body metabolises Effexor into Pristiq
Venlafaxine is active in the body before it is broken down into pristiq. If one looks at affinity charts you can see that venlafaxine has some affinity for the dopamine transporter. Desvenlafaxine has negligible affinity for this transporter, meaning the part that binds to that receptor may be on venlafaxine molecule or some other metabolite of venlafaxine that is not desvenlafaxine. Venlafaxine also seems to have a higher serotonin to norepinephrine ratio than desvenlafaxine, so these could explain some of the clinical differences.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual anhedonia. )
Country:USA
Currently taking 2.5 mg prozac, Multi B vitamin
poster:Conundrum
thread:994652
URL: http://www.dr-bob.org/babble/20110822/msgs/994809.html