Posted by joe schmoe on November 7, 2011, at 14:07:09
In reply to Re: Viibrid Treatment - 20mgs » joe schmoe, posted by Conundrum on November 7, 2011, at 13:50:57
> Good points. I wonder what the effects of activating those serotonergic post synaptic receptors are. I thought the antidepressant response of most SSRIs were in some way mediated through that receptor.
If I understand it correctly, excess serotonin "crawling" up out of the synapse onto the pre-synaptic dendrite will activate the inhibitory autoreceptors, which will reduce serotonin production in a feedback loop. The serotonin in the synapse, on the other hand, is activating the post-synaptic receptors which result in signals being carried across the synapse, which is what you want - easier transmission. If the viibryd gets in the synapse (due to an overly high concentration), it competes with the serotonin at these "transmission" receptors on the post-synaptic neuron, and interferes with signal transmission, effectively resulting in less serotonin activity in the synapse. I could be mistaken of course.
poster:joe schmoe
thread:994620
URL: http://www.dr-bob.org/babble/20111027/msgs/1001832.html