Posted by Chairman_MAO on November 10, 2011, at 7:37:49
In reply to Triple reuptake inhibitor GSK372475 fails., posted by SLS on November 10, 2011, at 6:42:27
> Hi.
>
> I found this extremely disappointing.
>
> I don't know what pre-clinical tests were used to indicate antidepressant activity for this drug. Perhaps these tests ought to be re-appraised.
>I'd have to read more about the drug's mechanism of action. How much is actually getting to the brain? How did they determine the effective dose?
If you have more information, I'll give you my opinion and/or get the opinion of someone who knows a lot more than I do.
If it is, at that dose, actually significantly blocking monoamine uptake, I think another study is in order. I just don't see how it could be any other way unless there is something else going on.
poster:Chairman_MAO
thread:1002099
URL: http://www.dr-bob.org/babble/20111110/msgs/1002104.html