Posted by Phidippus on December 1, 2011, at 23:39:12
In reply to Re: thinking about a benzo » g_g_g_unit, posted by SLS on December 1, 2011, at 7:19:43
A handful of case studies have shown Lyrica's efficacy in treating OCD. It is a glutamate antagonist and antagonizes Substance P, which seems to be implicated in the OCD circuit. Its GABA-ergic profile also helps with general anxiety.
I use it to treat migraines and neuralgia, however its benefits to my anxiety are significant.
Zonegran does a whole bunch of stuff, among those things, it is a potent glutamate antagonist.
The APA recommends augmentation treatment with glutamate antagonists when there is limited response in patients with OCD taking antidepressants. A lot of anticonvulsants are glutamate antagonists, so theoretically any one of them can be used. Topamax is a popular choice and probably has the most studies behind it. I only found one case study for Zonegran, however I have used myself and have benefited.
Eric
poster:Phidippus
thread:1003747
URL: http://www.dr-bob.org/babble/20111120/msgs/1004124.html