Posted by SLS on January 6, 2012, at 6:07:27
In reply to Re: high dose study of glycine for OCD » novelagent, posted by mogger on January 6, 2012, at 0:49:24
> I thought that nmda antagonists were supposed to help depression and ocd but i see that glycine is a co agonist whatever that means? Seems to be contradictory.
Glycine is an inhibitory neurotransmitter - sort of like GABA. However, glycine acts as an allosteric co-agonist with glutamate at the NMDA receptor complex to open the ion channel. Both glutamate and glycine must be attached to the NMDA receptor at the same time. This is confusing. Glycine reuptake inhibitors enhance the efficacy of antipsychotics.
I need to learn more about the glutamate-glycine functional relationship. It does seem contradictory.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1005283
URL: http://www.dr-bob.org/babble/20111226/msgs/1006494.html