Posted by SLS on February 5, 2012, at 7:52:31
In reply to Zyprexa and smokeless tobacco, posted by tensor on February 5, 2012, at 4:09:38
> It seems that smoking tobacco decreases plasma levels of Zyprexa, accordingly to the document below. Smokeless tobacco, which I use, does not seem to have this effect, what do you think?
>
> http://www.medscape.com/viewarticle/738621_3It seems that the enzyme-inducers (accelerators) must be generated through the combustion of tobacco (polycyclic aromatic hydrocarbons). Without combustion, tobacco has no effect on Zyprexa blood levels. I guess you figured this out already.
One unexpected thing I saw was that a compound being investigated for depression (TC-5214) is a ACh nicotinic receptor antagonist. It does the opposite of nicotine. However, another compound (CP-601,927) is a nicotinic receptor partial agonist. At first, this would seem contradictory. However, it is very selective for the alpha4beta2 receptor subtype. I would have to know more about this subtype in order to understand what's going on.
Is nicotine good for you? Is nicotine bad for you? I don't know. However, a drug called mecamylamine (Inversine) is being investigated for the treatment of depression. Mecamylamine is a ACh nicotinic receptor antagonist - again, doing the opposite of nicotine. Yet, acutely, nicotine fosters the release of dopamine. It might just be that acute administration of nicotine produces a transient antidepressant-like effect, while chronic administration of nicotine antagonists yield persistent antidepressant responses.
Things get even more complicated when one looks at the transient upregulation of nicotinic receptors that occurs between acute nicotine administrations. This might be the mechanism by which addiction develops. Also, BDNF inhibits nicotinic receptors in hippocampal.
This all begs the question, "What the hell is going on here?!"
Personally, I would stay away from tobacco, if for no other reason than to avoid oral cancer. I doubt that intermittent high-dose acute administration of nicotine enhances mood-stability over the long-term.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1009329
URL: http://www.dr-bob.org/babble/20120202/msgs/1009355.html