Posted by ed_uk2010 on March 1, 2012, at 1:43:54
In reply to Re: Toradol for migraine ? (on EMSAM) » ed_uk2010, posted by Phillipa on February 29, 2012, at 20:35:57
>Ed also it's listed as not being able to be taken with SSRIs for headaches.
The SSRI/sumatriptan combination has received more study than the MAOI/sumatriptan combination.
There is little evidence of a major interaction between MAOIs and sumatriptan, apart from decreased metabolism of the sumatriptan. The contra-indication is based somewhat on the theoretical possibility of a toxic reaction, but mainly on medico-legal considerations. It's a shame that the interaction hasn't received more study since depression and migraine commonly occur in the same patients.
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