Posted by SLS on March 1, 2012, at 13:00:10
In reply to Nortriptyline for 10 days now. Update, posted by Laney on March 1, 2012, at 11:13:54
> So I've been on it like 10 days. It's not working yet. It seems like it worked so quickly last time. How long do you think I should give it? My doc wants me up to 75mg. I'm at 50mg.
>
> What are the main differences between Nort. and Clomiprimine? Just looking ahead.
>
> Thanks as usual,
>
> Laney
Most people do not respond to nortriptyline until they reach a dosage of 75 mg. If you have a fast metabolism, you might need as much as 150 mg. For nortriptyline, it is worth getting a blood test for drug levels. I need 150 mg in order to respond. I am an "extensive metabolizer". My blood levels at 150 mg are still below the maximum. The reference range for the blood test is between 50 - 150 ng/ml.Nortriptyline is a unique drug among the tricyclics. Unlike the others, one can actually lose the antidepressant response if the dosage is too high. This phenomenon is known as a "therapeutic window".
I think it is too early to be worried at this point. It is unlikely that you would respond to 50 mg, even if you stayed at that dosage for a month.
I hope you are able to recapture you original response to nortriptyline. You'll let us know?
Good luck.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1012100
URL: http://www.dr-bob.org/babble/20120221/msgs/1012116.html