Posted by viper1431 on July 10, 2012, at 3:34:58
In reply to Why does Nardil cause urinary retention?, posted by gilmourr on July 9, 2012, at 16:24:11
Those are signs of other things too though, the hypotension etc are believed to be caused by the acetyl-seratonin thing rather than decreased NE.
There could be a few things that cause it, for eg increased NE and Adrenaline activating A2 receptors, that has some contracting effects on smooth muscle, as well as decreasing acetycholine which will cause things like urinary retention and dry mouth. As well as producing artery vasodilation which can lower BP.
Then you look at A1 recpetors stimulated by NE and adrenaline again and look at it's effects;
In smooth muscle of blood vessels the principal effect is vasoconstriction. Blood vessels with α1-adrenergic receptors are present in the skin, the sphincters[4] of gastrointestinal system, kidney (renal artery)[5] and brain.
Urethral sphincter
It also induces contraction of the urinary bladder[7][8], although this effect is minor compared to the relaxing effect of β2-adrenergic receptors. In other words, the overall effect of sympathetic stimuli on the bladder is relaxation, in order to delay micturition(peeing) during stress.So those are a few of the ideas i have as to why nardil can cause it.
> I just restarted Nardil. Urinary retention doesn't show up until I'm on it for about a month and it takes a higher dose, but how does it happen?
>
> It can't be increased NE. Increased NE causes smooth muscles to contract and urinary retention, but Nardil makes me have orthostatic hypotension, lower BP, and loss of energy which are all SIGNS OF LOW NE. So the urinary retention is definitely not from increased NE.
>
> What is in a MAOI or Nardil that causes this symptom???
poster:viper1431
thread:1021031
URL: http://www.dr-bob.org/babble/20120630/msgs/1021060.html