Posted by Novelagent on August 31, 2012, at 15:24:05
In reply to Re: help- trazodone stopped working » novelagent, posted by phidippus on August 28, 2012, at 20:03:21
Thanks. Does trazodone cause sexual dysfunction? It works now-- it turns out i was takibg vyvanse too late at 9:30AM; I take vyvanse no later than 9AM now.
> Mirtazapine is an antagonist/inverse agonist at the following receptors:[64][65]
>
> 5-HT1A receptor (Ki=18nM; IC50=1,000nM) [66]
> 5-HT2A receptor (Ki = 69 nM)
> 5-HT2B receptor (Ki = ? (~20-fold lower than for 5-HT2A/2C))[67]
> 5-HT2C receptor (Ki = 39 nM)
> 5-HT3 receptor (Ki = ? (similar to 5-HT2A/2C (mouse neuroblastoma cell)))[68]
> 5-HT7 receptor (Ki = 265 nM)
> α1-adrenergic receptor (Ki = 608 nM (rat))
> α2A-adrenergic receptor (Ki = 20 nM)
> α2B-adrenergic receptor (Ki = ? nM (likely similar to α2A/α2B-adrenergic))[citation needed]
> α2C-adrenergic receptor (Ki = 18 nM)
> H1 receptor (Ki = 1.6 nM)
> mACh receptors (Ki = 794 nM (rat))
> Dopamine D1 receptor (Ki=4,167nM) [69]
> Dopamine D2 receptor (Ki=1,460nM) [70]
> Dopamine D3 receptor (Ki=5,723nM) [71]
> Dopamine D4 receptor (Ki=25nM)
>
> In contrast to mirtazapine, the SSRIs, SNRIs, MAOIs, and some TCAs increase the general activity of the 5-HT2A, 5-HT2C, and 5-HT3 receptors leading to a host of negative changes and side effects, the most prominent of which include anorexia, insomnia, sexual dysfunction (loss of libido and anorgasmia),
>
> In addition, mirtazapine's antagonism of the 5-HT2A and 5-HT2C receptors has beneficial effects on anxiety, sleep and appetite, as well as sexual function regarding the latter receptor
>
>
> Eric
poster:Novelagent
thread:1023891
URL: http://www.dr-bob.org/babble/20120830/msgs/1024558.html