Posted by brynb on September 11, 2012, at 18:18:45
In reply to Re: Need out of the box suggestions » brynb, posted by phidippus on September 11, 2012, at 16:54:58
> Tramadol is a serotonin releasing agent, rather than a seratonin reuptake inhibitor. Tramadol also acts a μ-opioid receptor agonist, NMDA receptor antagonist, 5-HT2C receptor antagonist, (α7)5 nicotinic acetylcholine receptor antagonist, TRPV1 receptor agonist, norepinephrine reuptake inhibitor, and M1 and M3 muscarinic acetylcholine receptor antagonist.
>
> EricInteresting! Is it definitely a serotonin releasing agent? I've heard some say it releases it, and others claim it acts as a serotonin reuptake inhibitor. I'm confused :/. It's interesting, because I can't tolerate Cymbalta or Effexor. In fact, I've always done best on Lexapro, which leads me to think I'm a "serotonin" girl.
But, because of all the other ways Tramadol works (on mu/opiate receptors, on NMDA, etc.), it's probably got several things that are working in tandem to combat the depression.
What really pisses me off is that pdocs have this aversion to it when it works so well for so many people. I had no trouble stopping it (and NEVER abused it), have zero side effects from it, and have not become tolerant or dependent on it (I never increased the dose). And yet benzos, stims, opiates, heck, even anti-depressants are doled out as if they aren't habit forming. Ugh!
-b
poster:brynb
thread:1025287
URL: http://www.dr-bob.org/babble/20120830/msgs/1025419.html