Posted by SLS on September 23, 2012, at 11:56:33
In reply to Reinstated Luvox dosage causing new side effects?!, posted by Prefect on September 23, 2012, at 10:31:19
> -On 50 mg Luvox for 7 years for agoraphobia and panic disorder
>
> -6 months ago began tapering down very slowly
>
> -Relapsed last month after reaching 37.5 mg!
>
> -Reinstated original dose
>
> -Now I have involuntary muscle jerks just as I'm about to fall asleep, which jolt me awake, causing couple of hours of insomnia some nights. Also day time moments of odd feelings of tension mixed with slight mania/rage (lasts a couple of seconds at a time).
>
> Question: How can I have a side effect like this going back on the same dosage of a med I'd been on for 7 years without these side effects?!
>For how long have you had the side effects?
Did you have these side effects appear the first time Luvox was introduced?
Have your psychiatric symptoms lessened?
It would take a pretty smart neuroscientist to answer your question. However, weird things happen all the time with psychotropic drugs. The brain is not a static mechanism. It is plastic and dynamic. It reacts to change. Your changing the dosage of Luvox down and then up again probably elicited a sensitization reaction in a manner similar to how one reacts more strongly to cocaine after the brain is exposed to it a few times. Serotonin receptors may have had the opportunity to upregulate while at the lower dosage and are now resistant to downregulation. Things are usually not that simple, though. It could involve postsynaptic second messenger signalling. I really don't know.
Either way, I doubt that you are imagining these things. They might eventually disappear, but it can take some time.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1026421
URL: http://www.dr-bob.org/babble/20120922/msgs/1026422.html