Posted by Nootril on September 23, 2012, at 23:49:27
In reply to Re: Do antidepressants do more Harm than good ?, posted by jono_in_adelaide on September 23, 2012, at 22:13:54
I'm definitely not trying to discourage anybody who's taking anti-d's or is contemplating on starting. I myself am taking zoloft 100 mgs/day coupled with 100mgs/day of amantadine. I also take Aniracetam and Cerebrolysin. I've had a few concussions and have a small hemorrhage in the head of my left Caudate Nucleus, which is causing me great memory problems, attention deficits and depression with anxiety.
Zoloft is very good as it as affinity for the Sigma1 receptor, has moderate DRI properties at 100mgs and greater with some mild norepinephrine re-uptake demonstration as well.
I found this Journal abstract regarding Luvox, which is a very potent Sigma1 agonist , that demonstrates no cognitive problems according to some literature and a few users.http://www.ncbi.nlm.nih.gov/pubmed/20373470
I know Phillipa was taking it with 5 mgs of Lexapro but I think she is discontinuing it?
I'm wondering if anyone has been on it long enough to ascertain its anti-depressant effectiveness from Sigma-1 Agonism with minimal to no cognitive compromise.It's effect on sleep architecture are unremarkable but I also hear its one of the worst offenders for constant tiredness and fatigue.
I have the whole article regarding Luvox only via copy and paste if anyone is interested, as it was a 24 hour paid view from Wiley Online Library,Human Psychopharmacology.
poster:Nootril
thread:1026432
URL: http://www.dr-bob.org/babble/20120922/msgs/1026483.html