Posted by SLS on October 5, 2012, at 4:10:36
In reply to Re: I know that Busiparone doesn't do anything...., posted by linkadge on October 4, 2012, at 16:29:50
> The idea that buspar does nothing is not true.
>
> According to my psychiatrist, when it works, it can work remarkably well with very few side effects.
>
> My line of thinking is this. Even if the drug only caused a 15% drop in anxiety, this is worthwhile.
>
> Also benzos may cause dementia whereas buspar (as a 5-ht1a agonist) grows new brain cells (a recent study)
>
> LinkadgeThat is a very interesting and encouraging finding, since a growing number of antipsychotics have this property. Unfortunately, the only antidepressant that does this is Viibryd (vilazodone). Gepirone was not considered approvable by the FDA, despite multiple submissions, and other similar drugs have been abandoned. It is perhaps more unfortunate that there does not exist a mentality that psychotropic drugs can be worth developing that are effective as augmenters, despite not being effective as monotherapy. By contrast, this mentality does exist in the treatment of other illnesses like epilepsy, for which lamotrigine and gabapentin were developed and marketed as augmenters. Ritanserin is one drug that comes to mind that might have been worth approving as an augmenter of antidepressants because of its property of 5-HT2 antagonism. Unfortunately, it is now off-patent and doomed to remain available only to rodents.
Q: Do you think it is true that prior exposure to a benzodiazepine renders buspirone ineffective?
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1027523
URL: http://www.dr-bob.org/babble/20121001/msgs/1027724.html