Posted by g_g_g_unit on October 8, 2012, at 0:25:18
Can anyone here speculate why Memantine might be increasing my anxiety? I've titrated upwards quite slowly, in 2.5mg increments, and have recently reached 15mg. I've noticed that things are particularly bad for the first 3-4 days on a certain dose, but then level out a little after that; however, once I hit 10mg, the anxiety didn't really abate, and now, on my 3rd day taking 15mg, I feel incredibly tense, agitated, overstimulated, etc.
Is there a relationship between NMDA antagonism and catecholamine activity?
What's strange is that each time I dose, I get an acute, benzo-like effect (only cleaner) which is really promising, but only seems to last for an hour or two.
I've e-mailed two separate researchers who conducted studies on Memantine and OCD; one said anxiety was quite a rare side-effect, but when he encountered it, he titrated downwards until the patient adjusted to a given dose .. the other suggested titrating upwards, and that early anxiety might be a predictor of a positive response (as with SSRIs).
poster:g_g_g_unit
thread:1028002
URL: http://www.dr-bob.org/babble/20121001/msgs/1028002.html