Posted by ChicagoKat on October 13, 2012, at 15:21:53
In reply to Re: How right you were Scott » alchemy, posted by SLS on October 12, 2012, at 23:16:35
> > Hi Kat :) I'm going to start the Parnate journey sometime this week. Thanks for all of your encouragement.
> >
> > Scott - I am confused about the blood pressure things I read about MOAIs. I am going to start Parnate (lied to my dr. about being off Wellbutrin 2 weeks, I am still tapering but only at 50mg)
>
> I once added Wellbutrin to ongoing Parnate treatment. The combination is generally safe, although I cannot personally vouch for adding Parnate to an ongoing Wellbutrin treatment.
>
> > If they cause low blood pressure, why are we suppose to avoid foods because they will cause high blood pressure?
>
> The two effects operate via different mechanisms. Actually, scientists do not completely understand how MAOIs produce hypotension.
>
> http://www.dr-bob.org/babble/20040423/msgs/339682.html
>
> The tyramine pressor effect (hypertension) is more easily understood. Tyramine is not a neurotransmitter, nor does it bind to neurotransmitter receptors. When excess amounts of dietary tyramine enters the nerve cell, it displaces norepinephrine (NE) from synaptic vesicles and releases this NE into the synapse, thereby stimulating post-synaptic receptors and causing a rise in blood pressure. In effect, tyramine is kicking NE out of the cell. This released NE then stimulates receptors along blood vessels to produce vasoconstriction.
>
> It seems that the acute tyramine pressor effect (cheese reaction) is stronger than the hypotensive effects of the MAOI.
>
> > If parnate is stimulating, how can there be a stimulating effect along with low blood pressure?
>
> Unfortunately, there are instances wherein Parnate alone causes hypertensive reactions and limits its usage.
>
> > My blood pressure is always on the low side. Does that make parnate and/or the "scary" foods more or less of a risk?
>
> I don't know. My guess is that it really doesn't matter too much.
>
> The information I use may not be the most current. Perhaps someone can update us.
>
>
> - Scott
>
>
Nope, Scott, IMO you nailed it.And Alchemy, good luck with the Parnate. I truly hope it really helps you :)
Kat
poster:ChicagoKat
thread:1028313
URL: http://www.dr-bob.org/babble/20121009/msgs/1028538.html