Posted by zazenducke on October 17, 2012, at 18:54:54
In reply to For those of you on MAOIs--question, posted by Roslynn on October 17, 2012, at 14:58:01
Sublingual nifedipine has previously been used in hypertensive emergencies. This was found to be dangerous, and has been abandoned. Sublingual nifedipine causes blood-pressure lowering through peripheral vasodilation. It can cause an uncontrollable decrease in blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death. As a result of this, the FDA reviewed all data regarding the safety and efficacy of sublingual nifedipine for hypertensive emergencies in 1995, and concluded that the practice should be abandoned because it was neither safe nor efficacious.[5][6]
http://en.wikipedia.org/wiki/Nifedipine
This explains why sublingual nifedipine is not used.
poster:zazenducke
thread:1028972
URL: http://www.dr-bob.org/babble/20121009/msgs/1029003.html