Posted by gilmourr on December 1, 2012, at 9:09:25
In reply to Re: Blood Brain Barrier - any doctors for this? » jono_in_adelaide, posted by rjlockhart37 on November 30, 2012, at 23:20:24
I remember while I was reading at the library I briefly glossed over the blood brain barrier section in this pharma book.
I believe certain drugs automatically cross the blood brain barrier because of something added to them that lets it permeate the BBB. So the drug itself will ALWAYS do this.
The only exception is if you have some type of genetic mutation that doesn't allow drugs to pass your BBB and that is very uncommon. I'm not even sure if you can test for it or correct it.
In summary, you may be right that your drugs are not crossing the BBB or that way less then the targeted amount is getting through. However this is unlikely if you've had a response to ANY drugs. If no drugs have ever worked, it's likely you have this issue. If they work but don't work well then they are getting through the BBB, but it may not be well. In that case you'll just have to try every single med and see which one works best.
Or do ECT, VNS, or rTMS.
I am not sure whether a BBB genetic issue can be fixed. My instinct is saying probably not
poster:gilmourr
thread:1032198
URL: http://www.dr-bob.org/babble/20121130/msgs/1032264.html