Posted by SLS on December 20, 2012, at 15:09:26
In reply to Re: High fat diet -) inflammation -) depression » SLS, posted by Trotter on December 20, 2012, at 13:22:29
> The thesis I linked to in my previous post proved a causal link between high fat diet, invasive bowel bacteria and systemic inflammation. The following trials in mice provide strong causal link between high fat diets and depression. When taken together, this is further evidence of a causal relationship between inflammation and depression. That said, I'm sure you are right that people who already suffer from depression are more likely to suffer worse when experiencing systemic inflammation.
>
> http://psychcentral.com/news/2012/05/28/high-fat-diet-linked-to-depression-anxiety-in-mice/39295.html
> http://www.sciencedaily.com/releases/2012/12/121212092104.htm
>I still don't see a causal relationship being established here. Your first citation mentions the word inflammation once and indicates a line or reasoning why it is related to high-fat diets. However, the connection being made between inflammation and depression is still a correlate without proof of causation. It is a rather tenuous link to other people's work in that they pose the hypothesis that it "may lead to"...
"Other research has shown that food high in saturated fat such as hamburgers, bacon, pork sausages, cheese, butter, and ice cream cause inflammation in the body, including the brain, and that this inflammation may lead to negative mood states."
The second citation doesn't mention inflammation at all.
I am not willing to jump on the "inflammation causes depression" bandwagon just yet.
I don't know why diets high in animal fat and obesity are associated with depression. Is inflammation the common denominator? According to your citations, it seems as if changes in reward center activation, sensitivity, and gene expression are considered causal. Perhaps I am misinterpreting the articles.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1033371
URL: http://www.dr-bob.org/babble/20121217/msgs/1033397.html