Posted by SLS on March 19, 2013, at 6:54:38
In reply to MAOIs lower maintenance dose?, posted by vanvog on March 16, 2013, at 23:27:34
> I don't see much talked about the MAOIs being "different" insofar there is this concept of a high dose until full remission and a lower maintenance dose treatment in the long run. I'm pretty sure I've read it somewhere more than once but I don't know if some studies actually exist to back this strategy up. Has someone successfully lowered the dose after remission without returning symptoms and less efficacy?
If by remission, you mean being symptom free for a period of a year or more, then it might be possible. However, if by remission, you mean the initial response that reduces symptoms, I would say that it is unlikely. Sometimes, one can benefit from taking a slightly higher dosage to first establish MAO inhibition and then cut-back to maintain it. I doubt this would represent more than a 20% difference in dosage, though.
In my experience with Nardil and Parnate, I need the same dosage to maintain a response as it takes to establish it. However, I have not experienced a stable remission in 25 years, so I am really describing a partial response rather than sustained remission.
I have not personally seen any evidence of the phenomenon described in the package label of Nardil. I don't see that people who need 60 - 90 mg/day to respond go on to maintain the response at 15 - 30 mg/day as soon as the response emerges.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1040528
URL: http://www.dr-bob.org/babble/20130308/msgs/1040630.html