Posted by poser938 on March 25, 2013, at 21:18:05
In reply to Re: things are getting too difficult, posted by jono_in_adelaide on March 25, 2013, at 21:04:28
> Mirtazapine isnt an NARI (it works by inhibiting the alpha2 androreceptors, leading to noradrenalin release
>
> I still think it would be worth a shot, but by the same token, Zoloft would seem to be well worth a try, especialy as you have aquired tolorance to cyproheptadine.
>
> Another alternative would be doxepin (Sinequan), this is a potent antidepressant/antianxiety agebnt that isnt an NARI, it works by blocking various 5HT receptors. You could even take
this with Zoloft if needed, Zoloft in the morning and doxepin at night
>
> Very best of luck which ever way you choose to go.
>
>
>
> Best of luck!
>
>
Hmm.. well, I do get most of my basic pharmacology info from wikipedia and it is showing both of those work on the norepinephrine transporter.I do like the idea of alpha2 antagonism though.
poster:poser938
thread:1041047
URL: http://www.dr-bob.org/babble/20130322/msgs/1041080.html