Posted by Tomatheus on April 2, 2013, at 10:16:03
In reply to Re: To MAOI or not to MAOI » Tomatheus, posted by tensor on April 2, 2013, at 4:32:59
Tensor,
See below for my responses to your questions...
> Did you get to have an antidote to carry around with you for hypertensive crisis, like nifedipine?
No, I didn't. I probably should have at least asked my doctor about getting an antidote medication, but I never did. Then again, the nearest hospital to me isn't very far away. I never had a hypertensive crisis, but of course, they can occur.
> How fast does bp rise to dangerous levels should you ingest too much tyramine?
According to Sathyanarayana Rao & Yeragani (2009), hypertensive crisis episodes usually occur one to two hours after the intake of the offending food.
> Did you find the side effects bothersome?
For the most part, I didn't find the side effects of Nardil to be bothersome. I gained a little bit of weight on Nardil and experienced some lightheadedness and dizziness upon standing early on during the course of my trial with the medication, but those side effects didn't bother me too much. I also experienced excessive sweating and urinary retention on certain versions of Nardil, but not others, and although I didn't particularly care for those side effects, they never became so unbearable to prompt me to discontinue the medication. About two months into my trial with a slightly altered (enterically encapsulated) version of Nardil that Pfizer markets in the U.S. (which is where I live), I experienced extreme agitation, which along with a sudden loss of effectiveness, did prompt me to discontinue the medication. I suspect that the extreme agitation and the sudden loss of effectiveness that I experienced about two months after I started taking Pfizer's U.S. Nardil may have been brought on by a bad batch of the medication, which other Nardil users in the U.S. have reported, but I guess I can't be 100 percent sure about that.
The main side effect that I experienced on the U.S. version of Parnate (which was made by GlaxoSmithKline at the time) was afternoon drowsiness. Because I was taking classes in the afternoon and evening at the time I took the GlaxoSmithKline Parnate and ended up sleeping through the classes as a result, I did find this particular side effect to be bothersome, and it led me to discontinue the medication. Later, I tried the U.K. version of tranylcypromine (generic Parnate, and that version was made by Goldshield at the time) and did not experience afternoon drowsiness or any other side effects that I could recall.
I don't recall experiencing any side effects when I tried Marplan, but then again, I didn't keep taking the medication for very long because its therapeutic benefits were very short lived for me. I experienced some agitation and what I would describe as slight cognitive impairment when I took oral selegiline, which were somewhat bothersome. I don't know whether or not I would have tolerated the side effects that I experienced on selegiline into the long term, but the fact that my therapeutic benefits on the medication were short lived made the decision to discontinue the drug easy. I think I experienced some agitation from taking moclobemide, but I had been feeling very agitated prior to taking moclobemide and after I stopped taking it, so it was difficult to tell how much more agitated I might have been as a result of taking the medication.
Well, this sums up my responses to your questions. If you have any more questions for me, please feel free to ask.
Tomatheus
==
REFERENCE
Sathyanarayana Rao, T.S., & Yeragani, V.K. (2009). Hypertensive crisis and cheese. Indian Journal of Psychiatry, 51, 65-66. Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738414/
Dx: schizoaffective disorder
Treatments: Abilify & Korean ginseng
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