Posted by g_g_g_unit on June 20, 2013, at 10:08:15
In reply to Re: how about Riluzole? » g_g_g_unit, posted by SLS on June 20, 2013, at 9:32:27
> > I found this -- results from an open-label trial of Minocycline in OCD.
> >
> > "22% had a 40% to 46% YBOCS reduction at 12 weeks; the group as a whole did not have a significant change in YBOCS score."
> >
> > http://www.jneuroinflammation.com/content/10/1/43/table/T3
>
> Hmm.
>
> If riluzole were effective, I thought minocycline might be worth exploring because of its antiglutamatergic properties. I guess not.Do you know if Riluzole has the same potential as other anti-glutamatergics to cause dissociative/cognitive side-effects?
>
> Is there still work being done with memantine? Memantine is another drug with antiglutamatergic effects. It binds to the NMDA receptor.
>The last time I checked up, a promising double-blind trial had been completed in Iran. However, I gave up on pursuing Memantine after it exacerbated anxiety in me, despite giving numerous doses a couple of weeks respectively to produce a response.
From what I've read though, Memantine, NAC (which also didn't work) and Riluzole all reduce glutamate through different mechanisms, so if one didn't work, it doesn't rule out the possibility that another might.
> How does your OCD manifest?
>It's what's referred to as (somewhat misleadingly, I guess) "Pure O" -- mostly mental obsessions, few physical compulsions. Also accompanied by *a lot* of phobic avoidance, hyperarousal and, for the past 2-3 years, ongoing feels of depersonalization/derealization.
I have comorbid ADD. When my attention's improved, it gives me better control over the obsessions, but it's definitely no panacea.
poster:g_g_g_unit
thread:1045570
URL: http://www.dr-bob.org/babble/20130617/msgs/1045587.html