Posted by TriedEveryMedication on October 12, 2013, at 21:47:09
Does anyone here follow new drug news or what's in the pipeline?
Over the years I've seen a lot of things make it to phase III trials and then just quietly disappear.
Right now, new drugs:
Metadoxine - going into phase 3 trials for ADHD and fragile X. - "a nonstimulant 5-hydroxytryptamine receptor antagonist"... I think maybe a 5-HT3 agonist?
Levomilnacipran/Fetzima - just approved - some kind of minacipran derivative - SNRI
ALKS 5461/ Samidorphan-Buprenorphine combo - fast tracked for MDD. Seems fairly novel, a combo of μ-opioid antagonist and mu agonist.
Tedatioxetine - last I heard it was in phase II - serotonin, norepi and dopamine reuptake inhibitor
vortioxetine - SNRI-ish with some other stuff going on. Just approved by the FDA, scored superior to effexor and sweat-balta err, I mean cymbalta with fewer sides.
various orexin antagonists - Merck's got denied by the FDA, there were others; a lot of buzz on this receptor seems to have faded.
Pozanicline - a nicotinic receptor agonist, I thought it was in clinical trials, but it seems to have fallen off the map. Another fizzle?
Anything new you know about?
poster:TriedEveryMedication
thread:1052097
URL: http://www.dr-bob.org/babble/20130930/msgs/1052097.html