Posted by SLS on October 22, 2013, at 11:30:29
In reply to Re: Irving Kirsch, placebos and antidepressants » SLS, posted by doxogenic boy on October 22, 2013, at 8:45:25
This is good. Thanks.
Lauren Marangell is a respectable academician.
- Scott> > > Dopamine increases the motivation to act. Serotonin (ie. SSRIs) counteracts this. SSRIS decrease the motivation and drive to act or achieve things.
> >
> > Is this true of SSRIs even when they produce a robust antidepressant response, or is this associated only with non-response? I don't doubt that SSRI-induced apathy and amotivation are acute effects, but what happens after receptor desensitization occurs? Wouldn't these unwanted effects dissipate?
> --
>
> Isn't SSRI-induced apathy a long-term side effect of SSRIs?
>
> See this study:
> http://www.ncbi.nlm.nih.gov/pubmed/12019662
> Excerpt from the abstract above:
> J Clin Psychiatry. 2002 May;63(5):391-5.
> Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study.
> Marangell LB, Johnson CR, Kertz B, Zboyan HA, Martinez JM.
> Source
>
> Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA. laurenm@bcm.tmc.edu
> Abstract
> BACKGROUND:
>
> We report a clinical trial of olanzapine in the treatment of prominent apathy in the absence of depression in patients on long-term treatment with selective serotonin reuptake inhibitors (SSRIs) for nonpsychotic major depression.
> [...]
> CONCLUSION:
>
> These preliminary data suggest that olanzapine may be effective in treating apathy syndrome in nonpsychotic patients taking SSRIs.
> End quote.
>
> Do you know of patients with SSRI-induced apathy that have been helped with atypical antipsychotics?
>
> - doxogenic
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1052457
URL: http://www.dr-bob.org/babble/20130930/msgs/1052773.html