Posted by SLS on November 17, 2013, at 11:36:17
In reply to Re: Scott, can you enlighten me? (Nmda), posted by Lamdage22 on November 17, 2013, at 10:53:50
> > > Scott,
> > >
> > > how is it that sarcosine and glycine are good for schizophrenia as agonists and at the same time minocycline and lamictal are good as antagonists.
> >
> > I am not educated enough to answer your question.
> >
> > When glycine bonds to its sub-receptor of the NMDA receptor, it acts to reduce excess glutamateric activity. Minocycline and Lamictal reduce excess glutamatergic activity as well, albeit through different mechanisms.
> >
> > Sorry I couldn't help you with the sarcosine.
> >
> >
> >
> > - Scott
>
> Hi Scott,
>
> sarcosine is basically a "glycine reuptake inhibitor". It is making me a little nervous and akathisia like. I will probably change and try glycine instead. I suspect this reuptake inhibitor business gives me akathisia in general.
>
> Scott, i am responding to Acetylcysteine big time. Also i reacted to lamictal in a way that i didnt need antipsychotics anymore.
>
> Does this mean that i may be cured afterall?Perhaps you have managed to "squelch" noisy glutamatergic neuronal circuits by using drugs like:
1. NAC
2. Lamictal
3. MinocyclineI would not play with a direct-acting NMDA channel blocker like memantine or ketamine. I would stay away from sarcosine if it does what you describe pharmacologically.
I'll give this more thought. If I come up with anything, I will post.
I am excited to hear that your response to NAC was so rapid. With affective disorders, it can take as long as 6 months to take effect. Let's hope it "sticks".
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1054471
URL: http://www.dr-bob.org/babble/20131115/msgs/1054534.html