Posted by rose45 on February 14, 2014, at 13:57:39
In reply to Re: nardil tolerance and ensuing cognitive problems » rose45, posted by phinxeezaDr on February 9, 2014, at 20:39:42
> Hi. For what its worth I've been on MAOIs for 10yrs. Started on Nardil. WOW! It was amazing at 1st. I even asked my pdoc if I seemed hypo-manic to him but he simply replied that I had just come outa my box for the 1st time since very early childhood. I was on a high- a natural high. After this faded I still got a lot from Nardil. It made it easier to meet and blend with people esp at work. Then it became less effective and despite several addons it never worked as well as at the start. So I switched MAOIs. Marplan (isocarboxazid) certainly does not have that 'soul changing' effect of Nardil but it is still a very potent antidepressant. It just needs proper dosing, which unfortunately is a lot higher than the txt suggests. I take 90mg whilst the max remains at 60mg. The best thing about it tho is that it can be combined with a lot more meds than Nardil. I also take Seroquel which definitely accentuates my ADs (isocarboxazid, amitriptyline & bupropion). Yes, BUPROPION! Not a rout many docs would would consider going, but its actually quite safe. In fact several NRIs have been shown to protect from Hypertensive Crisis rather than precipitate them.
> Basically, try Marplan before taking the plunge with Parnate. I'm very surprised your doc didn't move to Marplan next. You can manipulate Marplan a lot more than the other 2. Also you might do better on a short acting benzo like Xanax which has a short half life meaning less addictive, if taken as needed. Best wishesThank you and everyone else for your feedback and suggestions.
For some reason, Marplan was never suggested. Maybe it is not used that much in the UK? Maybe I thought it was less powerful than nardil and parnate... ? I hated Seroquel and glad that Im only taking one medication. When you take so many, isnt it hard to know what is doing what? The good thing about parnate is that it began to work very fast, whereas I had horrible side effects with nardil for 8 weeks, and always when I changed the dose even slightly . In fact, it was so difficult to change the dosage, whereas parnate is much simpler. The main problem is not being able to sleep without sleeping pills. And Im gradually running out of ideas for sleep as the pills Im taking become less effective. Might see if my gp will give me xanax. They are very strict in the uk about prescribing benzos.
poster:rose45
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