Posted by LouisianaSportsman on May 2, 2014, at 12:43:58
In reply to Re: ^^ Above Post is for Klein-- this is about Aptiom, posted by LouisianaSportsman on May 1, 2014, at 21:13:50
Friday and Saturday after administering Oleptro ER the night before I woke up the next feeling the best I have felt in a LONG TIME.
Friday morning was decent, I'd say it was about 5/10 on the sluggishness scale which is pretty good since most days are 7-9's.
Today was a 3/10 on the sluggishness. I got out of bed within 2 minutes! I can't remember the last time I've done that.
Effects of trazodone on the sleep of depressed subjects a polygraphic study
Clinical improvement, as assessed by a reduction of more than 60% in MADRS scale scores, was accompanied by evidence of the definitely beneficial effects of trazodone on the disturbed sleep of these depressed patients. From the beginning of treatment, there was a hypnotic-like effect (increase in total duration of sleep and stage II, decrease in sleep latency and intrasleep awakenings). In addition, records at the end of the study showed an increase in delta sleep and an increase in REM latency, an effect classically associated with an antidepressant action. These particularly valuable effects of trazodone on sleep would suggest that this drug should especially be given in cases of depression with major insomnia.
----------------Discontinuing it and using it as a sleep aid.
Latuda and Brintellix basically do everything trazadone does:
Relevant actions of trazadone:
5-HT1A antagonism -- Latuda does that
5-HT1D antagonsim -- Brintellix has that covered
5-HT2A antagonism -- Latuda again
5-HT2B antagonism -- Brintellix does thatThere is mention about 5-HT2C antagonism but I see the binding affinity at 223.9? So... I guess it's got that going for it if it's really significant. I guess a little is going on at my 300mg. dose. The a1 adrenergic effect it has is mimicked by Latuda as well.
So, it mainly has 5HT-2a going for it where lurasidone antagonism is higher.
I can't find anything unique about trazadone except H1 antagonism, seriously. Maybe I should have been taking an antihistamine before bed all this time? I guess I miss out on negligible 5-HT2C antagonism, that's it.
I will be discontinuing Oleptro ER and breaking the 300mg. bisectable tablets in half and having a really, really quality sleep aid.
I've never thought about it, but generic modafinil and gabapentin should be pretty cheap right. I can pay for it without insurance. I will likely get that next time. Generic lamotrigine, not XL, would be cheap without insurance too, but I'm not complaining about getting off of it.
poster:LouisianaSportsman
thread:1065010
URL: http://www.dr-bob.org/babble/20140419/msgs/1065101.html