Posted by uncouth on July 1, 2014, at 16:40:27
In reply to Re: Scared to death of Mirapex, posted by enndub on July 1, 2014, at 16:23:39
honestly it poopped out probably a few weeks to maybe 1-2 months, not sure, but pretty soon. those receptors downregulate quickly given constant stimulation. DAs are weird too, esepcially mirapex, as it agnoizes presynaptic receptors at low doses before it gets to post.
i've heard of horror stories of mirapex withdrawal. i can't remember, but i did know i had to go off pretty slowly, decreasing doses over time. i know going off from 1.5mg right away is a bad deal for me...restless legs, mood, anhedonia etc.
really wish DAs could maintain effectiveness for me in the long term, i know they do for some people.
i may have posted in another thread, but i'm actually trying nardil with disulfiram for similar issues ( for me, mostly motivational issues, but dopamine nonethess). my pdoc says its fairly experimental and he's never done it before, but i'm seeing pretty great results for motivation and mood, though not so much for anorgasmia. was on it for about 5 weeks at 250-500mg, but went off last week because i wanted to drink for 4th of july, and to test out whether disulfarm was really having an impact with the nardil. i can confirm it was, so looking forward to going back on!
(disulfiram is also a dopamine beta hydroxilase inhibitor)
poster:uncouth
thread:1067533
URL: http://www.dr-bob.org/babble/20140609/msgs/1067724.html