Posted by phidippus on November 10, 2014, at 17:08:06
In reply to What's the deal w/ Tianeptine, posted by crabcakebenny on November 5, 2014, at 22:13:10
"it is known to serve as a selective serotonin reuptake enhancer, although more recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of AMPA and NMDA glutamate receptor activity and altered neuroplasticity and release of BDNF"
"Tianeptine research was revolutionised in July 2014 with publication of the unexpected discovery that tianeptine is a full agonist at the μ and δ opioid receptors with negligible effect at the κ opioid receptors. Selective μ opioid agonists in the brain's "hedonic hotspots" typically induce euphoria...the delta opioid receptors may be critical to tianeptine's mood-brightening and anxiolytic effect - a therapeutic action seemingly unaccompanied by the physiological tolerance and dependence that have plagued traditional opioids" ~ Wikipedia
It seems its anxiolytic effects are very strong and has been compared to paroxetine in the treatment of panic disorder.
Its effects are not built up, but rather immediate. Think of Xanax, but even shorter lasting.
Eric
ps. Why do people complain about numbing of emotions while on drugs? I take 5 different medications and never experience a flattening of affect. I still cry, I still get pissed. I'm no robot.
poster:phidippus
thread:1073237
URL: http://www.dr-bob.org/babble/20141017/msgs/1073335.html