Posted by ed_uk2010 on November 22, 2014, at 20:05:09
In reply to take clomipramine and desipramine together?, posted by Joe Rogan on November 21, 2014, at 13:00:42
>is that safe?
Well, that really depends on doses, ECG monitoring, other medication taken, medical history, genetic differences in drug metabolizing enzymes etc. There is no easy answer to that question.
It's a lot easier to answer the question.... is is logical?
In general, no. And it's extremely uncommon to combine those two meds as a result. You see, although clomipramine itself is a potent serotonin reuptake inhibitor (amongst other things), one of it's major active metabolites, produced in the liver, is a powerful norepinephrine reuptake inhibitor called desmethylclomipramine... which is actually rather similar to desipramine (the full name for desipramine is desmethylimipramine).
I would not recommend this combination.
>or would taking venlafaxine be better?
Better in what sense? What are you being treated for and why are you considering changing meds?
poster:ed_uk2010
thread:1073644
URL: http://www.dr-bob.org/babble/20141120/msgs/1073690.html